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After it cracked the atom, humanity thrived - for a while. The US may have developed nuclear-powered cars, directed energy weapons, and advanced robots, but by 2052 the world was on the brink of collapse, a global energy crisis having led to widespread "resource wars". On the morning of October 2077, a two-hour nuclear exchange between rival nations resulted in devastation on an apocalyptic scale. Only the very fortunate survived the destruction, many of them sequestered in government-sanctioned science experiments, known as "Vaults".

Two centuries later, and post-apocalyptic America is ruled by rival factions, each vying for control over the former thirteen commonwealths. Ordinary citizens eke out a living in makeshift settlements, or by taking their chances against the wasteland's mutated wildlife, roaming bandit gangs, and deadly radiation storms.

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